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Whole-body imaging for spinal metastasis of breast cancer. Fluorescence was first detected in the lumbar spine at 1 min after the ICG-lactosome injection (A), and its intensity remained high until 24 h (B, C, D, and E). The fluorescence intensity in the lumbar spine of the rats with hind-limb paralysis was also high, and no other lesions were detected (F and G).
