Table 1.
Non-Exhaustive list of γ-Secretase Inhibitors and Modulators with Representative Classes and Scaffolds
| γ-Secretase Inhibitors | γ-Secretase Modulators | |||||
|---|---|---|---|---|---|---|
| Docking Sitea | Active Sitea | Allosteric Sitea | Nucleotide-Binding Sitea | Allosteric Sitea | Substrate Bindinga | |
| D-10 D-13 | L-685,458 III-31-C | DAPT Cpd-E LY-411,575 LY-450,139 BMS-433,796 | MRK-560 GSI-953 BMS-299,897 BMS-708,163 | Gleevec Sirtinol ZM-39923 | Sulindac sulfide Indomethacin CHF5074 EVP-0962 E-2012 GSM-1 | Flurbiprofen-BpB |
| Val-Gly-Aib-Val-Val-Ile-Aib-Thr-Val-Aib-X |  |
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a
Putative Binding Site of Compounds.