Figure 2.

Three dimensional projections of PET images of ¹¹C-verapamil radioactivity in pregnant Macaca nemestrina before (A) and during (B) administration of cyclosporine A (CsA; 12 mg/kg/h). Fetal liver was the reporter of ¹¹C-radioactivity that crossed the placental barrier. Because of P-gp inhibition, CsA significantly increased the distribution of ¹¹C-radioactivity into fetal liver. Thus, the fetal liver is seen in the figure only in B (indicated by yellow arrows). MH, maternal head; MK, maternal kidneys; ML, maternal liver; UW, uterine wall. Based on studies conducted by Eyal et al. (2009).