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. Author manuscript; available in PMC: 2012 Oct 6.
Published in final edited form as: Neuron. 2011 Oct 6;72(1):22–40. doi: 10.1016/j.neuron.2011.09.018

Figure 2. FOXO transcription factors drive neuronal polarization.

Figure 2

FOXO transcription factors occupy the Pak1 gene promoter and induce its expression to promote neuronal polarization. The kinase Pak1 regulates actin and microtubules dynamics by distinct mechanisms at the nascent axon and is required for neuronal polarization. A number of additional FOXO putative transcriptional targets, including mPar6, APC, Kif5A and CRMP-2 regulate polarization by acting locally at the nascent axon. The Par complex protein mPar3 is targeted to the nascent axon by APC. The microtubule-associated protein CRMP-2 is transported to the axon by Kif5A.