Table 2.
Bivariable and Multivariable Associations for Predictors of Frequent Intravaginal Cleansing During Follow-Up
| Characteristic | Visits at which women reported frequent cleansing n (%) | Bivariable OR (95% CI) | Multivariable OR (95% CI) |
|---|---|---|---|
| Treatment assignment | |||
| Diaphragm with Acidform™ | 71 (40.1) | 0.56 (0.30-1.05) | 0.37 (0.16-0.84) |
| Diaphragm with HEC | 104 (54.2) | 0.93 (0.49-1.79) | 0.97 (0.48-1.95) |
| Acidform only | 110 (57.6) | 1.08 (0.56-2.08) | 1.14 (0.60-2.17) |
| HEC only (referent) | 106 (55.2) | 1 | 1 |
| Site | |||
| Mahajanga | 160 (85.1) | 42.54 (19.30-93.77) | 37.3 (16.35-85.12) |
| Toamasina | 145 (75.5) | 22.63 (11.46-44.68) | 17.84 (8.02-39.69) |
| Antsiranana | 64 (35.6) | 4.10 (2.18-7.70) | 3.12 (1.50-6.45) |
| Antananarivo (referent) | 22 (11.5) | 1 | 1 |
| Cohabitation/marriage | |||
| Never married, noncohabiting | 210 (62.3) | 7.50 (3.34-16.84) | 3.41 (1.16-9.97) |
| Ever married, noncohabiting | 166 (50.8) | 4.93 (2.19-11.08) | 2.44 (0.88-6.76) |
| Cohabiting (referent) | 15 (17.1) | 1 | 1 |
| Coital frequency, past week | |||
| 18+ | 161 (63.6) | 1.69 (1.20-2.39) | 1.80 (1.10-2.96) |
| 11–17 | 132 (50.6) | 1.21 (0.88-1.66) | 1.35 (0.84-2.18) |
| <11 (referent) | 98 (41.2) | 1 | 1 |
| Intravaginal cleansing at enrollment, past week | |||
| 28+times | 146 (61.9) | 2.56 (1.27-5.17) | 2.52 (1.17-5.41) |
| 21–27 times | 105 (52.5) | 1.74 (0.85-3.56) | 1.93 (0.92-4.07) |
| 14–20 times | 82 (46.6) | 1.38 (0.66-2.88) | 1.73 (0.72-4.15) |
| <14 times (referent) | 58 (41.4) | 1 | 1 |
Generalized estimating equations (GEE) were used to account for repeated measurements on the same participant. Multivariable ORs and CIs reflect adjustment for all variables presented here plus study visit and adherence to study product use during sex.
CI, confidence interval; OR, odds ratio.