Fig. 7.

Predicted structure of Neisseria gonorrhoeae TbpA plug domain. (A) Wild-type; (B) Mutant (EIEYE → EIAAA). The EIEYE sequence is postulated to be important for iron transport functions. Tyrosine side chains are shown as wire-frames. The possible importance of the “Top Hat” region (red circle) for interaction with transferrin is discussed in the text. The model was created with I-TASSER based on amino acids 25–187 from NCBI sequence YP_208545.