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. Author manuscript; available in PMC: 2012 Jul 9.
Published in final edited form as: Pain. 2010 Oct 30;152(1):140–149. doi: 10.1016/j.pain.2010.10.002

Figure 2.

Figure 2

Time course changes in the average responses of Aδ and C-units meningeal nociceptors following topical application of TNF-α (100 ng/ml) and the effect of co-application of the TNF-α blocker Peg-sTNFR1 (1.5 mg/ml). A. Mean ± SEM response magnitude to mechanical stimulation of the dura using threshold (top) and suprathreshold (middle) pressure stimuli, and ongoing firing rate (bottom) at baseline with SIF, during TNF-α treatment and during the wash with SIF. B. Time course changes in the mean ± SEM responses to TNF-α in the presence of its blocker Peg-sTNFR1. Note the lack of TNF-evoked sensitization in the presence of the blocker.