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. Author manuscript; available in PMC: 2012 Jul 9.
Published in final edited form as: Pain. 2010 Oct 30;152(1):140–149. doi: 10.1016/j.pain.2010.10.002

Figure 4.

Figure 4

TNF-α evoked meningeal nociceptors’ sensitization involves p38 MAP kinase. Median, 10th, 25th, 75th and 90th percentile changes in threshold (A) and suprathreshold (B) responses of meningeal nociceptors to mechanical stimulation of the dura 60 min following application of TNF-α alone (in the presence of SIF), TNF-α in the presence of the p38 inhibitor SB203580 (SB), or SB203580 alone (in the presence of SIF). Note the blockade of TNF-α evoked sensitization by SB203580 and the lack of effect of this drug on baseline values. (* p<0.05 Wilcoxon test, 60 min after drug vs. baseline). C. Average number of pp38 labeled dural blood vessels observed per visual field following topical application of TNF-α or SIF (# p<0.05, Mann Whitney test TNF-α vs. SIF).