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. Author manuscript; available in PMC: 2012 Jul 9.
Published in final edited form as: Glia. 2011 Jun 2;59(10):1489–1502. doi: 10.1002/glia.21191

Fig. 6.

Fig. 6

Deletion of CHOP leads to an attenuation of the UPR after SCI. A: Total RNA was extracted from injury epicenter of WT and CHOP KO mice 6-h post-SCI. qRT-PCR data showed significant reductions in the expression of GRP78, GADD34, ATF4, and XBP1 mRNAs in CHOP KO (black bars) mice when compared with WT (white bars) mice. B: DR5 mRNA levels, analyzed by qRT-PCR, were significantly reduced at the injury epicenter in CHOP KO mice (black bars) when compared with WT (white bars) mice 6 and 72-h post-SCI. DR5 mRNA levels (normalized to Gapdh) is expressed as fold changes compared with levels in sham controls. Data (A, B) are the mean ± SD (n = 4, **P < 0.01, ***P < 0.001).