Table 1.
Correlations between myeloid-derived suppressor cells percentages and colorectal carcinoma clinical parameters
| Clinical parameters | Cases |
MDSC proportion in peripheral blood |
MDSC proportion in CRC tumor tissues |
||||
| Low | High | P value | Low | High | P value | ||
| Gender | 0.252 | 1.000 | |||||
| Male | 26 | 14 | 12 | 12 | 14 | ||
| Female | 23 | 8 | 15 | 11 | 12 | ||
| Age (yr) | 0.229 | 0.292 | |||||
| < 60 | 16 | 5 | 11 | 8 | 18 | ||
| ≥ 60 | 33 | 17 | 16 | 15 | 18 | ||
| Tumor size (cm) | 1.000 | 0.571 | |||||
| ≤ 5 | 24 | 11 | 13 | 10 | 14 | ||
| > 5 | 25 | 11 | 14 | 13 | 12 | ||
| Tumor (T) status1 | 0.179 | 0.466 | |||||
| pT1 | 4 | 2 | 2 | 1 | 3 | ||
| pT2 | 10 | 6 | 4 | 5 | 5 | ||
| pT3 | 12 | 9 | 5 | 4 | 8 | ||
| pT4 | 23 | 7 | 16 | 13 | 10 | ||
| Nodal (N) status2 | 0.248 | 0.016a | |||||
| N0 | 31 | 16 | 15 | 19 | 12 | ||
| N1 | 18 | 6 | 12 | 4 | 14 | ||
| Distant metastasis (M)3 | 0.023a | 0.047a | |||||
| M0 | 22 | 14 | 8 | 14 | 8 | ||
| M1 | 27 | 8 | 19 | 9 | 18 | ||
| TNM stage | 0.207 | 0.028a | |||||
| I | 6 | 2 | 4 | 2 | 4 | ||
| II | 12 | 7 | 5 | 8 | 4 | ||
| III | 11 | 7 | 4 | 8 | 3 | ||
| IV | 20 | 6 | 14 | 5 | 15 | ||
| Total | 49 | 22 | 27 | 23 | 26 | ||
1
Tumor status is classified as: pT1, invasion of lamina propria or submucosa; pT2, invasion of muscularis propria; pT3, invasion of adventitia; pT4, invasion of adjacent structures;
2
Nodal status is classified as: N0, no regional lymph-node metastasis; N1, regional lymph-node metastasis;
3
Distant metastasis is classified as follows: M0, no distant metastasis; M1, metastasis to cervical nodes, celiac nodes, and other distant metastases.
a
P < 0.05 was considered statistically significant. MDSC: Myeloid-derived suppressor cells; CRC: Colorectal carcinoma; TNM: Tumor, nodes, metastasis.