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Tg(PrP106)Prnp0/0 mice were inoculated with RML106 prions containing PrPSc106. Sections of the hippocampus were stained with hematoxylin and eosin (A and C) and immunostained for GFAP (B and D). (A and B) Control Tg(PrP106)Prnp0/0 mouse uninoculated and without neurologic deficits. (C and D) Tg(PrP106)Prnp0/0 mouse inoculated with RML106 prions and sacrificed after signs of neurologic dysfunction were observed. (Bar = 50 μm.) Photomicrographs prepared by Stephen J. DeArmond.
