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Development of different European and US flow charts proposed in the last decade for the diagnosis of HCC. AFP has progressively disappeared from the variables used for the diagnosis. Flow-chart (a): from Bruix et al. EASL guidelines 2001 [2], with modifications; flow chart (b): from Bruix et al. AASLD guidelines 2005 [3], with modifications; flow-chart (c): from EASL-EORTC guidelines 2012 [4], with modifications.
