Table 5.

ESC suggested recommendation for empirical antibiotic therapy in endocarditis

		Dose, route, duration
NVE & Late PVE	Ampicillin Sulbactam (Amoxicillin Clavulanate) plus Gentamicine Or Vancomycin Plus Gentamicin Plus Ciprofloxacin	12 g/ day iv in 4 doses 4 - 6 W 3 mg/kg/day in 2- 3 doses iv/im 4 -6 W 30 mg/ kg/day in 2 doses IV 4 - 6 W 3 mg/kg/day in 2-3 doses iv/im 4 - 6 W 1000 mg/day in 2 doses orally 4 - 6 W Or 800 mg/day in 2 doses iv
Early PVE	Vancomycin Plus Gentamicin Plus Rifampin	30 mg/ kg/day in 2 doses IV 6 W 3 mg/kg/day in 2-3 doses iv/im 2 W 1200 mg/day in 2 doses orally

NVE - native valve endocarditis; PVE - prosthetic valve endocarditis, W- weeks

Adapted from reference (3)