TABLE VI.
Candidate Genes on Chromosomes 6 and 10
| Candidate gene | Chromosome | Description |
|---|---|---|
| EPHA7 | 6 | Ligand involved in the repulsion of axonal growth cones and migrating cells |
| FUT9 | 6 | Synthesizes the Lewis X oligosaccharide is expressed in organ buds during embryogenesis and is developmentally regulated. Functions in cell to cell interaction during neuronal development |
| MANEA | 6 | Secretory pathway glycosylation enzyme found in mitochondria |
| CHUK | 10 | Essential for NFKB activation during limb and craniofacial development |
| CRTAC1 | 10 | An extracellular matrix protein expressed in bone, cartilage, and cultured chondrocytes |
| CSPG6 | 10 | Chondroitin sulfate proteoglycan |
| FBXW4 | 10 | Involved in signaling pathways crucial for normal limb development/split-hand/foot malformation |
| FER1L3 | 10 | Connected to muscular dystrophies |
| HABP2 | 10 | Glycosaminoglycan that is present in the extracellular matrix, connective tissue, cartilage, bone marrow, and synovial fluid |
| HTR7 | 10 | Serotonin receptor, regulatory effects on osteoclast development |
| KAZALD1 | 10 | Promotes proliferation of osteoblastic cells |
| LBX1 | 10 | Expressed during embryogenesis, expression restricted to developing CNS and muscles |
| LOXL4 | 10 | Cross-linking of collagen fibrils and insoluble elastic fibers in ECM, expressed in hypertrophic/calcified chondrocytes/growth plates |
| NFKB2 | 10 | Bone development/knockout mouse model of osteopetrosis due to a defect in osteoclast differentiation |
| NRAP | 10 | Giant myofibrillar proteins found within the sarcomeres of skeletal muscle |
| PLCE1 | 10 | Initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression |
| SEMA4G | 10 | Belongs to the semaphorin family, axonal guidance, and development in the A/P axis between the doral and ventral margins of the trunk and tail (zebrafish) |
| SFRP5 | 10 | Member of “frizzled” family of proteins/function as receptors for WNT genes |
| SL1T1 | 10 | Play a critical role in central nervous system midline formation |
| SUFU | 10 | Part of the Sonic Hedgehog signaling pathway/neural tube development |
| TLL2 | 10 | Structurally related to BMP-I/functions in ECM formation |
| WNT8 | 10 | WNT genes encode intercellular signaling glycoproteins that play important roles in key processes of embryonic development such as mesoderm induction, specification of the embryonic axis, and patterning of the central nervous system, spinal cord, and limbs |