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(A) N-acetyl cysteine (NAC) reduces phosphorylation of both Y705 and S727 Stat3 in HUVECs, both in normoxia (N), and following H/R. (B) Densitometry of 3 blots, with data normalized for Stat3 (loading control). Values represent mean ± SEM. ** p<0.01 for indicated comparison.