Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Evaluation of CuBox Catalysts and Iodonium Counterions
| ||||||
|---|---|---|---|---|---|---|
| entry | catalyst | X | temp. (°C) | A:B | yield (%)a | ee (%)b |
| 1 | None | OTf | 23 | -- | 0 | -- |
| 2 | (CuOTf)2•PhMe | OTf | 23 | 29:1 | 69 | -- |
| 3 | 1 | OTf | 23 | 4:1 | 20 | 8 |
| 4 | 2 | OTf | 23 | 3:1 | 71 | 61 |
| 5 | 3 | OTf | 23 | 1:10 | 90 | 98 |
| 6 | 3 | PF6 | 23 | 1:16 | 99 | 98 |
| 7 | 3 | AsF6 | 23 | 1:17 | 99 | 98 |
| 8 | 3 | AsF6 | −20 | 1:40 | 96 | >99 |
Isolated yield.
Determined by chiral HPLC analysis; absolute configuration determined by chemical correlation or by analogy.
