Table 4:

Top 5 Gene Ontology molecular functions for the components of the most active networks (Networks 1 and 2) using DAVID.

Network	Components	Top overall network functions	Molecular function of component genes (identified by DAVID)	P-value
1	CCL5, COL16A1, COL3A1, COL5A1, COL5A2, collagen, Collagen Alpha1, Collagen type I, Collagen type IV, Collagen(s), CSF1R, CTSB, CTSK, Elastase, ENTPD1, ERK1/2, Fibrinogen, FLI1, GRN, IL1, Laminin, Laminin1, LDL, Mek, Mmp, MMP2, MMP7, P38 MAPK, Pdgf (complex), PDGF BB, PLA2G5, SLC1A1, Tgf beta, TGFBI, THY1	Connective Tissue Disorders, Genetic Disorder, Connective Tissue Development and Function	Integrin binding	6.7E-7
			Protein complex binding	8.0E-5
			Extracellular matrix structural constituent	4.9E-3
			Endopeptidase activity	1.0E-2
			Platelet-derived growth factor binding	1.3E-2
2	ANXA4, BCL11B, CD3, CD8, CD3G, CD8A, CLEC7A, CORO1A, HLA-B, HLADMA, HLA-DMB, HLA-DPB1, HLADQB1 (includes others), HLA-DR, HLADRA, Hla-Drb, HLA-DRB1, IFN Beta, Ifn gamma, IgG, IL-2R, IL12 (complex), IL2RG, Interferon alpha, LCK, MHC, MHC Class I (complex), Mhc class ii, MHC Class II (complex), MHC II-β, Mhc2 Alpha, NFAT (complex), NFkB (complex), TCR, TNFAIP2	Genetic Disorder, Skeletal and Muscular Disorders, Cell-To-Cell Signaling and Interaction	MHC class II receptor activity	7.5E-12
			MHC protein binding	1.1E-8
			MHC class I protein binding	5.5E-7
			Phosphoinositide 3-kinase binding	1.1E-2
			Peptide binding	2.0E-2