Table 2.
Current drugs for AD and PD, and their targets.
| Drug | Disease | Targeta |
|---|---|---|
| Levodopa/carbidopa/entacapone | PD | COMT, DDC |
| Bromocriptine | PD | DRD1, DRD2 |
| Selegiline | PD | MAOB |
| Pramipexole | PD | DRD1,DRD2,DRD3,DRD4,DRD5 |
| Ropinirole | PD | DRD1,DRD2,DRD3,DRD4,DRD5 |
| Amantadine | PD | DRD2,DRD5 |
| Rasagiline | PD | MAOB |
| Donepezil | AD | ACHE |
| Rivastigmine | AD | ACHE,BCHE |
| Galantamine | AD | ACHE |
| Memantine | AD | CHRNA4,GRIN1,GRIN2A,GRIN2B, GRIN2C,GRIN2D, GRIN3A, GRIN3B, HTR3A |
a:
full names of drug targets: COMT: catechol-O-methyltransferase; DDC: dopa decarboxylase; DRD: dopamine receptor D; MAOB: monoamine oxidase B; ACHE: acetylcholinesterase; BCHE: butyrylcholinesterase; CHRNA4: cholinergic receptor, nicotinic, alpha 4; GRIN: glutamate receptor, ionotropic, N-methyl D-aspartate; HTR3A: 5-hydroxytryptamine (serotonin) receptor 3A.