Figure 2.
A, Reduced gray matter density in lvPPA (orange) affects regions of auditory association cortex (white) that were activated by the Sound word category in an fMRI study of healthy participants (blue). Note that the fMRI activation results (blue) represent a single cluster that is split in two along the superior temporal sulcus in this inflated cortical rendering. B, Slices showing overlap (green) of reduced gray matter density in lvPPA and fMRI activation for the Sound word category in healthy participants. C, Relationship between gray matter density and impaired performance on the Sound word category in lvPPA participants. This analysis was performed within the peak voxel of activation to Sound words from the fMRI study of healthy participants (MNI coordinates: −68, −32, 4). Similar findings were obtained for a 10 mm sphere centered on this peak voxel.