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. 2012 May 4;21(15):3397–3407. doi: 10.1093/hmg/dds172

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© The Author 2012. Published by Oxford University Press

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Inhibition of SPL activity increases S1P but does not inhibit cystogenesis in jck mice. Male jck mice were treated from 26–64 days of age with 50 mg/l THI in the drinking water. (A) Quantitative analysis of kidney/body weight ratio (K/BW), cyst volume and BUN from jck mice treated with THI or vehicle controls. Data shown are the mean ± SEM, n = 10 vehicle and 8 THI-treated animals. (B) Representative H&E-stained sections from THI-treated jck mice or vehicle controls. (C) LC-MS analysis of bioactive SL levels in kidneys of THI- or vehicle-treated jck mice. *P < 0.05 compared with vehicle. (D) LC-MS analysis of structural GSL levels in kidneys of THI- or vehicle-treated jck mice. Data shown are the mean ± SEM of three representative animals.