Figure 1.

Embryonic lethality upon simultaneous deregulation of Atm and Hus1. Embryos from timed matings were isolated at the indicated stage of embryonic development, imaged for morphological assesment and genotyped by PCR. (A–D) Representative images of Hus1^neo/Δ1nAtm^−/− embryos and control littermates from E8.5 to E11.5. (E–H) Representative images of Hus1^neo/neoAtm^−/− embryos and control littermates from E13.5 to E16.5. Note that, at E14.5, some Hus1^neo/neoAtm^−/− embryos are dead, whereas others are smaller than control littermates but otherwise normal.