Table 1.
Synthetic lethality following combined impairment of Hus1 and Atm in micea
| Hus1 genotype | Atm genotype | Number expected | Number observed |
|---|---|---|---|
| +/+ | 3 | 5 | |
| +/neo | 95 | 108 | |
| +/Δ1n | +/+ | 12 | 9 |
| neo/neo | 259 | 286 | |
| neo/Δ1n | 69 | 58 | |
| +/+ | 6 | 5 | |
| +/neo | 190 | 208 | |
| +/Δ1n | +/− | 24 | 31 |
| neo/neo | 518 | 659 | |
| neo/Δ1n | 138 | 190 | |
| +/+ | 3 | 4 | |
| +/neo | 95 | 93 | |
| +/Δ1n | −/− | 12 | 13 |
| neo/neo | 259 | 84 | |
| neo/Δ1n | 69 | 0 | |
| TOTAL | 1753 | 1753 |
a Mice were genotyped by PCR analysis of tail DNA at 3 weeks of age. Expected values represent the combined Mendelian ratios from several crosses involving different parental genotypes. The observed and expected genotype frequencies were significantly different (P<0.001; χ2 test).