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SERCA2a activity is regulated by its reversible inhibitor PLN, SUMO and the histidine rich Ca-binding protein (HRC). Phosphorylation of PLN is mediated by cAMP-dependent or Ca-CAM-dependent PKs and dephosphorylation occurs by protein phosphatase 1 (PP1). The activity of PP1 is regulated by inhibitor-1 (I-1).
