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There are three domains: cytosolic domain Ia, containing the phosphorylated Ser16 and Thr17 sites, cytosolic domain Ib and transmembrane domain II, containing AA that are important in pentamer stabilization and functional regulation of SERCA2a. The PLN monomer interacts with SERCA2a and inhibits its activity, while PLN phosphorylation leads to pentameric assembly and relief of the PLN inhibitory effects.
