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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: Gene. 2011 Nov 3;492(1):1–18. doi: 10.1016/j.gene.2011.10.044

Table 2.

Summary of bone phenotypes in mouse models of altered Wnt signaling in osteoclasts and precursors.

Gene CKO/CKI Cre line Bone phenotype(s) References
Ctnnb1 (β-Catenin) CKO PPARγ-tTA: TRE-Cre: exon6 Het mice: Osteoporosis, increased bone resorption, no change in bone formation; KO mice: Osteopetrosis, reduced bone resorption, reduced osteoclast precursor proliferation, no change in bone formation Wei et al., 2011
CKO Tie2-Cre: exon6 Het: Osteoporosis; KO: partial embryonic lethality, osteopetrosis
CKO Lyz-Cre: exon6 KO: Osteoporosis, increased bone resorption; Het: intermediate bone loss
CKO Ctsk-Cre: exon 6 Ibid
CKI/GOF Tie2-Cre: exon3 Embryonic lethality
CKI/GOF PPARγ-tTA: TRE-Cre: exon3 Osteopetrosis: more immature proliferating osteoclasts but fewer mature osteoclasts, reduced bone resorption, no change in bone formation
CKI/GOF Lyz-Cre: exon3 Ibid
CKI/GOF Ctsk-Cre: exon 3 Ibid

BMD: bone mineral density; CKI: conditional knock-in; CKO: conditional knockout mouse; Het: heterozygous knockout mouse.