Table S1.
Known copy number variations in humans
| Variation ID | ALDH | Type | Gain/loss | Site | Sample size (variant/controls) | Chr |
|---|---|---|---|---|---|---|
| 26310 | 16A1 | InDel | Gain | Intron | 1/1 | 19q13.33 |
| 26311 | 16A1 | InDel | Gain | Intron | 1/1 | 19q13.33 |
| 26312 | 16A1 | InDel | Gain | Intron | 1/1 | 19q13.33 |
| 26313 | 16A1 | InDel | Loss | Intron | 1/1 | 19q13.33 |
| 109892 | 1A1 | InDel | Gain | Intron | 1/1 | 9q21.13 |
| 102109 | 1A2 | CNV | Loss | Intron | 1/1 | 15q22.1 |
| 25534 | 1A2 | InDel | Loss | Intron | 1/1 | 15q22.1 |
| 40101 | 1A2 | InDel | Loss | Intron | 1/1 | 15q22.1 |
| 41386 | 1A2 | InDel | Loss | Intron | 1/1 | 15q22.1 |
| 45349 | 1A2 | InDel | Loss | Intron | 1/1 | 15q22.1 |
| 45350 | 1A2 | InDel | Loss | Intron | 1/1 | 15q22.1 |
| 102186 | 1A3 | CNV | Loss | Intron | 1/1 | 15q26.3 |
| 11819 | 1A3 | InDel | Loss | Intron | 1/36 | 15q26.3 |
| 25599 | 1A3 | InDel | Loss | Intron | 1/1 | 15q26.3 |
| 25600 | 1A3 | InDel | Loss | Intron | 1/1 | 15q26.3 |
| 25601 | 1A3 | InDel | Loss | Intron | 1/1 | 15q26.3 |
| 40124 | 1A3 | InDel | Loss | Intron | 1/2 | 15q26.3 |
| 42429 | 1A3 | InDel | Loss | Intron | 1/1 | 15q26.3 |
| 42898 | 1A3 | InDel | Loss | Intron | 1/1 | 15q26.3 |
| 45395 | 1A3 | InDel | Loss | Intron | 1/1 | 15q26.3 |
| 61482 | 1A3 | InDel | Loss | Intron | 1/1 | 15q26.3 |
| 68446 | 1L1 | InDel | Loss | Intron | 1/39 | 3q21.2 |
| 106822 | 1L2 | CNV | Gain | Intron | 1/1 | 12q23.3 |
| 42760 | 3A2 | InDel | Loss | Intron | 1/1 | 17p11.2 |
| 24787 | 3B2 | InDel | Loss | Intron | 1/1 | 11q13.2 |
| 44926 | 3B2 | InDel | Loss | Intron | 1/1 | 11q13.2 |
| 81276 | 5A1 | InDel | Gain | Intron | 1/90 | 6p22.2 |
| 93550 | 5A1 | CNV | Loss | Intron | 2/90 | 6p22.2 |
| 99466 | 5A1 | CNV | Loss | Intron | 1/1 | 6p22.2 |
| 33982 | 7A1 | InDel | Gain | Intron | 1/1 | 5q23.2 |
| 97538 | 9A1 | InDel | Gain | Intron | 1/1 | 1q24.1 |
| 23991 | 9A1 | InDel | Gain | Intron | 1/1 | 1q24.1 |
| 11004 | 9A1 | InDel | Loss | Intron | 15/50 | 1q24.1 |
| 35661 | 16A1 | CNV | Gain | Part | 1/1 | 19q13.33 |
| 114045 | 1A3 | CNV | Gain | Part | 1/30 | 15q26.3 |
| 72379 | 1A3 | CNV | Loss | Part | 1/39 | 15q26.3 |
| 4352 | 1L1 | CNV | 2G 1L | Part | 3/95 | 3q21.2 |
| 59786 | 1L1 | Inv | Inversion | Part | 1/1 | 3q21.2 |
| 68445 | 1L1 | CNV | Loss | Part | 1/39 | 3q21.2 |
| 107014 | 1L2 | CNV | Loss | Part | 1/1 | 12q23.3 |
| 88379 | 3A2 | CNV | Loss | Part | 1/90 | 17p11.2 |
| 88381 | 3A2 | CNV | Loss | Part | 1/90 | 17p11.2 |
| 3140 | 3A2 | CNV | Loss | Part | 4/270 | 17p11.2 |
| 65982 | 3B2 | CNV | Gain | Part | 2/450 | 11q13.2 |
| 85827 | 3B2 | CNV | Loss | Part | 2/90 | 11q13.2 |
| 53128 | 3B2 | CNV | Loss | Part | 2/1064 | 11q13.2 |
| 3055 | 6A1 | CNV | Gain | Part | 1/270 | 14q24.3 |
| 66668 | 6A1 | CNV | Loss | Part | 2/450 | 14q24.3 |
| 6793 | 9A1 | CNV | Loss | Part | 2/50 | 1q24.1 |
| 3856 | 3B1 | CNV | Gain/loss | Whole | 3/270 | 11q13.2 |
| 113072 | 3B1 | CNV | Gain | Whole | 1/30 | 11q13.2 |
| 30558 | 3B1 | CNV | Gain | Whole | 1/1 | 11q13.2 |
| 5275 | 3B2 | CNV | Gain | Whole | 1/272 | 11q13.1-11q13.2 |
| 5111 | 16A1 | CNV | Loss | Whole | 25/95 | 19q13.33 |
| 32261 | 16A1 | CNV | Loss | Whole | 18/30 | 19q13.32-19q13.33 |
| 5110 | 16A1 | CNV | Loss | Whole | 4/95 | 19q13.33 |
| 2201 | 1A3 | CNV | Loss | Whole | 3/269 | 15q26.3 |
| 47939 | 1B1 | CNV | Loss | Whole | 6/2906 | 9p13.1 |
| 30022 | 3A1 | CNV | Loss | Whole | 2/485 | 17p11.2 |
| 53160 | 3B1 | CNV | Loss | Whole | 2/1064 | 11q13.2 |
| 2931 | 3B1 | CNV | Loss | Whole | 8/270 | 11q13.2 |
| 29913 | 3B1 | CNV | Loss | Whole | 1/485 | 11q13.2 |
| 29914 | 3B1 | CNV | Loss | Whole | 1/485 | 11q13.2 |
| 47969 | 5A1 | CNV | Loss | Whole | 9/2906 | 6p22.2 |
Included are the variation ID from the Database of Genomic Variants, ALDH family member, type (CNV - copy number variation with changes > 1 kb; InDel - insertions and deletions with changes 100-999 bp; inv --inversions with changes that invert the nucleotide sequence), whether the change was a loss or gain, site (intron -- change only affects an intronic region; part -- change affects one or more exons; whole -- change affects the entire gene), sample size and chromosomal location