Table 1. Changes in mean arterial pressure (MAP), heart rate and arterial blood gases during hypoxia and reoxygenation.
Normoxic Baseline | End of hypoxia | Reoxygenation | |||
30 min | 2 h | 4 h | |||
MAP (mmHg) | |||||
H-R Control | 68±5 | 28±3§ | 47±4§ | 42±3§ | 34±3§ |
CSA 2.5 mg/kg | 78±3 | 31±2§ | 48±5§ | 41±3§ | 44±3§ |
CSA 10 mg/kg | 72±2 | 31±2§ | 54±6§ | 40±2§ | 38±2§ |
Sham-operated | 68±3 | 57±4* | 50±3 | 49±2 | 45±2* |
Heart Rate (bpm) | |||||
H-R Control | 181±12 | 213±8 | 211±9 | 225±9 | 216±11 |
CSA 2.5 mg/kg | 167±7 | 210±9§ | 185±8 | 191±10 | 207±14 |
CSA 10 mg/kg | 162±9 | 212±8§ | 199±7§ | 214±8 | 211±10§ |
Sham-operated | 204±17 | 237±10 | 232±7 | 231±3 | 221±8 |
pH | |||||
H-R Control | 7.41±0.06 | 7.08±0.07§ | 7.19±0.09§ | 7.31±0.07 | 7.31±0.12 |
CSA 2.5 mg/kg | 7.39±0.08 | 7.02±0.15§ | 7.14±0.16§ | 7.35±0.09 | 7.35±0.08 |
CSA 10 mg/kg | 7.43±0.05 | 7.05±0.17§ | 7.16±0.17§ | 7.35±0.07 | 7.35±0.04 |
Sham-operated | 7.39±0.02 | 7.39±0.02* | 7.42±0.02* | 7.39±0.02 | 7.41±0.04 |
PaO2 (mmHg) | |||||
H-R Control | 74±13 | 37±8§ | 348±96§ | 62±6 | 63±16 |
CSA 2.5 mg/kg | 83±9 | 36±6§ | 383±86§ | 63±8 | 63±4 |
CSA 10 mg/kg | 79±13 | 36±8§ | 413±36§ | 69±6 | 64±4 |
Sham-operated | 67±5 | 68±3* | 68±4* | 77±18 | 76±17 |
PCO2 (mmHg) | |||||
H-R Control | 39±3 | 39±5 | 37±4 | 39±3 | 39±4 |
CSA 2.5 mg/kg | 39±4 | 42±4 | 39±5 | 36±3 | 42±3 |
CSA 10 mg/kg | 37±4 | 39±5 | 36±5 | 38±3 | 41±3 |
Sham-operated | 37±2 | 41±3 | 40±6 | 40±3 | 37±3 |
Base excess (mmol/L) | |||||
H-R Control | 0.1±3 | −17±3§ | −13±3§ | −6±3 | −5±2 |
CSA 2.5 mg/kg | −1.0±3 | −18±5§ | −14±6§ | −5±5 | −2±5 |
CSA 10 mg/kg | 0.5±2 | −17±6§ | −14±6§ | −4±4 | −2±2 |
Sham-operated | −2.0±2 | −0.3±1* | 1.5±3* | −0.9±3 | −0.8±2 |
Plasma Lactate (mmol/L) | |||||
H-R Control | 4±1 | 14±4§ | 11±3§ | 7±2 | 6±3 |
CSA 2.5 mg/kg | 4±1 | 15±4§ | 11±3§ | 5±2 | 3±2 |
CSA 10 mg/kg | 4±1 | 14±5§ | 12±4§ | 6±3 | 3±1 |
Sham-operated | 4±2 | 3±1* | 2±1* | 2±1 | 2±1 |
p<0.05 vs. normoxic baseline (2-way repeated measures ANOVA).
p<0.05 vs. H-R controls (2-way repeated measures ANOVA).