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. 2012 Jul 9;7(7):e40469. doi: 10.1371/journal.pone.0040469

Figure 2. Organization of dome structure on plastic substratum.

Figure 2

A: Development of inter-connecting structure (arrow head) between domes (arrows) in BuMECs monolayer attached to plastic substratum (×40); B: Magnified view of dome and inter-connecting structure shown in bracket in Fig. A (×100); C: Phase contrast microscopic image of an intermediate stage in the process of development of interconnecting structure (arrow head) between domes (arrow) (×100); D: Branching pattern of interconnecting structure between domes (×100); E: Magnified view of inter-connecting structure with focus on the monolayer (×400); F: Magnified view of interconnecting structure with focus on the top of the structure showing cells above the substratum (×400). This is a unique observation in BuMECs. These inter-connecting structures may represent contact mediated differentiation of BuMECs on plastic substratum.