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. 2012 Jul 9;7(7):e39396. doi: 10.1371/journal.pone.0039396

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Nikerel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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fig:ObjSpace represents the objective space, where each feasibility criterion is taken along (no cutoff is used in this plot). fig:CombinedObj presents a 3D plot of the feasible enzyme space fig:CombinedObjLayers presents decompositions of the feasible enzyme space into a series of 2D slices, each differing by the value of (indicated on the plot). Blue points describe the functionally feasible enzyme levels ( i.e. fluxes with top 25% are considered as feasible), red points are homeostatically feasible enzyme levels (), green points are the feasible enzyme levels considering the temporal responsiveness and black points are the states that are feasible for all three criteria.

Inline graphic — fig:ObjSpace represents the objective space, where each feasibility criterion is taken along (no cutoff is used in this plot). fig:CombinedObj presents a 3D plot of the feasible enzyme space fig:CombinedObjLayers presents decompositions of the feasible enzyme space into a series of 2D slices, each differing by the value of (indicated on the plot). Blue points describe the functionally feasible enzyme levels ( i.e. fluxes with top 25% are considered as feasible), red points are homeostatically feasible enzyme levels (), green points are the feasible enzyme levels considering the temporal responsiveness and black points are the states that are feasible for all three criteria.