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. 2012 Jul 9;7(7):e39396. doi: 10.1371/journal.pone.0039396

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Nikerel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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on on the feasible enzyme space with respect to homeostasis ( ) and function ( ). fig:HomeostasisEv1x2: The feasible enzyme space for (left), (center), and (right). In every subplot, red points: solely homeostatically feasible enzyme levels; blue points: solely functionally feasible enzyme levels; black points: feasible enzyme levels on both criteria. The axes for all 3 plots are the same, enzyme levels relative to the reference state. fig:AdditionalFeedbackEv1x2-MetLev: The maximum achievable metabolite levels as function of the inhibition strength.

Inline graphic — on on the feasible enzyme space with respect to homeostasis ( ) and function ( ). fig:HomeostasisEv1x2: The feasible enzyme space for (left), (center), and (right). In every subplot, red points: solely homeostatically feasible enzyme levels; blue points: solely functionally feasible enzyme levels; black points: feasible enzyme levels on both criteria. The axes for all 3 plots are the same, enzyme levels relative to the reference state. fig:AdditionalFeedbackEv1x2-MetLev: The maximum achievable metabolite levels as function of the inhibition strength.