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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Neuropharmacology. 2012 May 8;63(4):514–523. doi: 10.1016/j.neuropharm.2012.04.024

Fig. 6. CB2 activation by 2-AG does not alter GIRK or outward currents.

Fig. 6

A) 2-AG (5 μM) did not alter peak inwardly rectifying potassium currents observed while hyperpolarizing CB2-transfected neurons to −130mV after a brief depolarization to −50mV. These currents are reliably elicited by postsynaptic GABAB (25μM baclofen, n=5) and adenosine A1 (200 nM N6-cyclopentyladenosine, n=4) receptor activation in wild type neurons. Top trace: representative 2-AG treatment of CB2 expressing neuron. Bottom trace: representative trace for a baclofen treated neuron. Scale bars: 500pA, 50msec. B) Current-Voltage plot shows that peak outward currents in response to successive voltage steps are unaltered by application of 2-AG (5μM) in CB2-expressing neurons. p<0.05 for GABAB and Adenosine A1 vs. CB2 using one way ANOVA with Dunnett's posthoc test.