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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Neuropharmacology. 2012 May 8;63(4):514–523. doi: 10.1016/j.neuropharm.2012.04.024

Fig. 8. CB2 inhibits neurotransmission through inhibition of voltage gated calcium channels.

Fig. 8

(A,B) In CB2 expressing CB1 null neurons, exchanging the external medium with medium containing 0.2 mM CaCl2 (low Ca2+) increases the inter-event interval of sEPSCs (n=9). The low Ca2+ medium occludes the inverse agonist effect of AM630 observed in Fig. 7. (C) Exchanging the medium with low Ca2+ does not alter sEPSC amplitude. AM630 also has no further effect on sEPSC amplitude (n=9). Data in (B) and (C) analyzed using one-way ANOVA with Bonferroni's multiple comparison test.