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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Adv Drug Deliv Rev. 2012 Mar 26;64(12):1331–1340. doi: 10.1016/j.addr.2012.03.013

TABLE 5.

In vivo gene delivery to bone

Transgene Vector Model References
BMP-2 Adenovirus Rabbit femur segmental defect (42)
BMP-2 Adenovirus Infected rabbit femur segmental defect (49)
BMP-2 Adenovirus Rat femur segmental defect (43, 111, 112)
BMP-2 Adenovirus Distraction osteogenesis–rat mandible (113)
BMP-6 Adenovirus Rabbit ulna, horse metatarsal (44, 114)
BMP-2, BMP-9 Adenovirus Rat mandible (115)
BMP-4; COX-2; LMP-1 Retrovirus Rat femoral fracture (116–118)
VEGF Adenovirus Rat femur drilling (119)
VEGF Adenovirus Rabbit avascular necrosis (120)
BMP-9; BMP-2
BMP-2 + BMP-7		 Adenovirus Rat spine fusion (121, 122)
BMP-6 Adenovirus Rabbit spine fusion (123)
BMP-7 Plasmid Rat spine fusion (124)
BMP-2 Adenovirus Sheep tibial defect (45, 46)
BMP-9 Plasmid (electroporation) Mouse radial non-union (125)

COX-2: cyclooxygenase-2