TABLE 6.
Gene delivery to bone using traditional ex vivo methods
| Transgene | Vector | Model | References |
|---|---|---|---|
| BMP-2 | Adenovirus | Rodent long bone | (52, 59, 126) |
| IGF-1* | Plasmid* | (26) | |
| VEGF | Plasmid | (55) | |
| BMP-4 | Retrovirus | (53) | |
| BMP-2 | Lentivirus | (54, 66) | |
| FGF-2 | Plasmid | Rabbit radial defect | (127) |
| BMP-2, -7 | Retrovirus, Adenovirus | Rodent cranial defect | (128) (129) |
| BMP-4 + VEGF | Adenovirus | (130) | |
| Cbfa1 | Adenovirus | (131) | |
| Osterix | Retrovirus | (132) | |
| LMP-1 | Plasmid – liposomes | Rat spine fusion | (133) |
| BMP-7 | Adenovirus | (134) | |
| BMP-2 | Adenovirus | (135) | |
| BMP-2 | Adenovirus; lentivirus | (136) | |
| BMP-2 | Adenovirus | Mouse spine fusion | (137) |
| BMP-2 | Adenovirus | Rabbit spine fusion | (135) |
| BMP-2 | Liposomes, Adenovirus | Rat mandibular defect | (138) |
| LMP-3 | Adenovirus | (139) | |
| Hepatocyte growth factor | Adenovirus | Avascular necrosis | (140) |
| BMP-2 | Adenovirus | Goat Tibial defect | (141, 142) |
| BMP-2 | Adenovirus | Horse Metatarsus/metacarpus Rib | (143, 144) |
| BMP-2 | Adenovirus | Goat, avascular necrosis | (145) |
| BMP-2 | Adenovirus | Pig, cranial defect | (146) |
| BMP-6 | Plasmid (nucleofection) | Rat, vertebral defect | (147) |
*
stably transfected cell line