Table 2.
Expression levels of three genes surrounding the case-associated haplotype in healthy dogs showing all three genotypes.
| Genotypea | Amountb | Increasec | Pd | |
|---|---|---|---|---|
| CDKN2A | 2 | 0.002577 | 16.8988 | 0.0173 |
| 1 | 0.001334 | 8.7482 | >0.05 | |
| 0 | 0.000153 | 1 | ||
| CDKN2B | 2 | 0.000697 | 3.976 | 0.0087 |
| 1 | 0.000518 | 2.9567 | >0.05 | |
| 0 | 0.000175 | 1 | ||
| MTAP | 2 | 0.009758 | 1.2412 | >0.05 |
| 1 | 0.009028 | 1.1484 | >0.05 | |
| 0 | 0.007862 | 1 |
a
The genotype is the number of copies of the case associated (CA) haplotype with 2=homozygous for the CA haplotype, 1=heterozygous, and 0 = no copies of the CA haplotype.
b
The amount of transcript is relative to the amount of B2M transcript and normalized by comparison to expression in testes.
c
Increase in expression of each gene in individuals carrying the CA haplotype compared to those without.
d
p-values were calculated by Wilcoxon rank sum on the distribution of relative expression levels within each genotype group.