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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: J Immunol. 2012 Jun 13;189(2):906–915. doi: 10.4049/jimmunol.1200257

Fig. 7. Proposed model of LTB4/BLT1 regulation of GM-CSF and PU.1 expression and enhancement of dectin-1 expression and responsiveness.

Fig. 7

Basal or dectin-1-activated LTB4/BLT1 signaling elicits Gαi activation that results in enhanced expression of GM-CSF. This cytokine potentiates expression of PU.1, which carries out transcription of dectin-1, augmenting dectin-1 protein expression and responsiveness, as evidenced by binding, phagocytosis, cytokine secretion, and neutrophil recruitment in response to challenge with C. albicans, zymosan, or the fungal glucan curdlan. LTB4 generation in response to dectin-1 ligation represents an autocrine self-amplifying loop.