Table 4.

Association of study measurements with organ dysfunction, inflammation, and clinical outcome in septic patients^a

	ADMA		Arginine		Arg:ADMA
	rs	p	rs	p	rs	p
Organ Dysfunction
PIM-2	−0.02	0.93	0.02	0.95	0.08	0.81
PELOD	−0.50	0.009	−0.11	0.74	0.29	0.37
Inotrope scoreb	−0.11	0.60	−0.08	0.81	−0.03	0.92
ALT	0.25	0.26	0.30	0.39	0.09	0.80
Total bilirubin	−0.26	0.24	0.53	0.12	0.21	0.56
Creatinine	0.23	0.26	0.21	0.52	0.06	0.86
BNP	0.07	0.79	−0.09	0.80	−0.42	0.23
Lactate	0.39	0.14	0.12	0.78	−0.07	0.87
Inflammation
WBC	0.76	<0.001c	−0.10	0.75	−0.36	0.25
CRP	−0.15	0.51	0.16	0.62	0.01	1.0
Interleukin-6	−0.55	0.01	0.22	0.50	0.32	0.31
Interleukin-8	−0.52	0.03	0.22	0.52	0.26	0.45
Clinical Outcome
ICU LOS	0.22	0.88	0.19	0.56	0.06	0.86
Hospital LOS	0.26	0.29	0.09	0.79	0.18	0.59
Inotrope-free days	−0.12	0.57	−0.25	0.44	−0.22	0.48
Ventilator-free days	−0.29	0.15	−0.28	0.37	−0.21	0.52

ADMA, asymmetric dimethylarginine; Arg:ADMA, arginine:asymmetric dimethylarginine ratio; PIM-2, Pediatric Index of Mortality-2 score, PELOD, Pediatric Logistic Organ Dysfunction score; ALT, alanine aminotransferase; BNP, brain natriuretic peptide; WBC, white blood cell count; CRP, c-reactive protein; LOS, length of stay;

^aSpearman’s rank correlation coefficient (r_s) and coefficient of determination (r²) refer to day 1 values

^bInotrope score = dopamine + dobutamine + (nor-/epinephrine × 100) + (milrinone × 10) + (vasopressin × 10) (28)

^cSurvived correction for multiple testing at p<0.003