. Author manuscript; available in PMC: 2013 Jul 15.

Published in final edited form as: J Immunol. 2012 Jun 20;189(2):988–1001. doi: 10.4049/jimmunol.1103031

Table I.

Number of genes regulated between the groups compared in mouse models and human and overlapping with human datasets.

Mouse model	Groups compared	Genes regulated^a	Corresponding human orthologous genes	Overlap with 3159 genes^a regulated in human glomerular LN^b	Overlap with 2261 genes^a regulated in human tubulointerstitial LN^b	Genes regulated in murine and human LN in both renal compartments^b
NZB/W	23 wks Pre-N compared to 16 wks control	234	203	58	56	29
	23 wks N compared to 16 wks control	919	826	315	242	177
	23 wks N compared to 23 wks Pre-N	1382	1227	375	309	200
	36 wks N compared to 23 weeks Pre-N	2642^*	2442	631	379	242
	36 wks N compared to 16 wks control	3201	2972	674	385	244
NZM2410	30 wks N compared to 7wks control	4015^*	3727	699	467	251
NZW/BXSB	17 wks Pre-N compared to 8 wks control	319	302	95	79	48
	18–21 wks N compared to 8 wks control	1877	1757	568	384	246
	18–21 wks N compared to 17 wks Pre-N	2900^*	2652	622	447	268

q-value<0.05 and fold-change ≥ 1.2 for the up-regulated genes and ≤ 0.8 for the down-regulated genes.

genes regulated in same directionality in regulation.

Groups with highest level of shared nodes in network analysis used for further studies. Legend: N: Nephritic (proteinuria > 300mg/dl, histologic nephritis score > 2), Pre-N: Pre-nephritic (serum autoantibodies, proteinuria ≤ 100mg/dl, histologic nephritis score ≤ 2), wks: weeks.