Table 2.
PET Imaging Analyses: Right Ventromedial Caudate
| SNP | Female N | Male N | x,y,z Coordinates, mma | Cluster Sizeb | F scorec | Corrected P Valued |
|---|---|---|---|---|---|---|
| rs4813625 | (n=28GG=10, GC=12, CC=6) | n=22 (GG=8, GC=12, CC=2) | 6, 16, 2 | 500 | 12.71 | 0.01** |
| rs877172 | n=32 (AA=13, AC=16, CC=3) | n=23 (AA=10, AC=8, CC=5) | 6, 16, 3 | 128 | 5.84 | 0.78# |
| rs3761248 | (n=32TT=19, TC=13, CC=0) | n=23 (TT=14, TC=6, CC=3) | 6, 17, 2 | 729 | 9.99 | 0.06# |
| rs2740210 | n=31 (TT=4, TG=10, GG=17) | n=22 (TT=3, TG=6, GG=13) | ----- | ----- | ----- |
a
Indicates the Montreal Neurological Institute coordinates for the peak voxel
b
Cluster size expressed in 13-mm voxels
c
Peak-voxel statistics obtained via ANCOVA within the right ventromedial caudate.
d
Peak-voxel P value after multiple comparisons correction (FWE)
**
Significant differences between genotype groups after multiple comparisons correction (FWE) and correction for four SNPs (Bonferroni).
#
Effects noted within the right ventromedial caudate for these SNPs albeit below the stringent FWE threshold. Uncorrected p-values: rs3761248 (p<0.0001) and rs877172 (p=0.0016).