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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2012 Jul;60(1):88–99. doi: 10.1097/FJC.0b013e3182588b00

FIGURE 7. Effect of expression of SkM1 on angular velocity (AV) of AP propagation.

FIGURE 7

(A) Phase graphs of re-entrant propagation induced in a myocyte only sample and a myocyte-HEK293-SkM1 sample in 5.4 mM K+ or 9 mM K+ Tyrode’s solution. Phase movies were generated in Metlab software from macroscopic optical mapping data. The color bar shows the fluorescence intensity of the Ca2+ signal. The black line shows the wave front of the propagation. Frames were analyzed every 0.1s to determine the propagation speed. (B) AV of induced re-entry at different K+ concentrations. Data are expressed as mean±SE, n = 7 for each group. (r/s: rotations/sec). Two way ANOVA (Holm-Sidak) test showed a significant difference between Myocyte only and Myocyte-HEK293-SkM1 (P<0.001), and between Myocyte-HEK293-SCN5A and Myocyte-HEK293-SkM1 (P<0.001), but no difference between Myocyte only and Myocyte-HEK293-SCN5A.