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. Author manuscript; available in PMC: 2013 Jul 9.
Published in final edited form as: Biomacromolecules. 2012 Jun 5;13(7):2154–2162. doi: 10.1021/bm300545b

Figure 5. Relationships between hydrophobicity and skin retention of the surface modified G2 dendrimers.

Figure 5

A) Partition coefficients of various G2 PAMAM dendrimers measured using the shake-flask method. The experimental groups include G2-RITC-COOH, G2-RITC-Ac, G2-RITC-NH2, and two types of OA-conjugated dendrimers: G2-RITC-NH2-OA2.3 and G2-RITC-NH2-OA2.7. The observed higher skin deposition of the G2-RITC-NH2-OA conjugates is likely a result of their higher partition coefficients than other types of dendrimers. B) Skin deposition and retention of various G2 PAMAM dendrimers and their conjugates after 24 h of the Franz cell experiment (error bars: standard error from the donor solution, n=3).