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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2012 Apr 13;11(7):1565–1575. doi: 10.1158/1535-7163.MCT-11-0938

Figure 6. Dose reduction of dexamethasone for the reversal of PF-03084014-induced gastrointestinal toxicity.

Figure 6

(A) Periodic acid-Schiff (PAS) stain of distal ileum sections harvested from mice treated for 5 days with vehicle, dexamethasone (1mg/kg, 5mg/kg, or 15mg/kg), 150mg/kg PF-03084014, or dexamethasone plus PF-03084014. (B) Hematoxylin and eosin (H&E) stain of spleens and thymii harvested from mice in (A). Scale bars represent 50µm (intestines) or 400µm (spleen, thymus).