Table 1.

Chromosomal Loci with linkage to AMD based on family studies and corresponding candidate genes as determined by case-control association studies

Linkage Study	Chromosomal Loci (Chromosomes 1 – 8)
WEEKS (Weeks et al., 2000)											5q32
WEEKS (Weeks et al., 2001)	1q31
WEEKS (Weeks et al., 2004)
SCHICK (Schick et al., 2003)	1q31		2q14.3
MAJEWSKI (Majewski et al., 2003)					3					5q12 - 13			6q14-21
BARRAL (Barral et al., 2006)	1q31				3p13			4q32
ABECASIS (Abecasis et al., 2004)	1q				3p								6q25.2
IYENGAR (Iyengar et al., 2004)	1q	2p							5p
SEDDON (Seddon et al., 2003)	1q31	2p21					4p16				5q34
SANTANGELO* (Santangelo et al., 2005)	1q	2p24		2q37		3q						6p		8p23
JUN# (Jun et al., 2005)	1q25-q31			2q31-32									6q25.3
Possible genes within the linkage locus(loci)	CFH 1q32			CYP27A1 2q37 MREG 2q35	MYRIP 3p22 ROBO1 3p12	COL8A1 3q12.3		CFI 4q25	C7 5p13			C2/BF 6p21 VEGFA 6p12	FRK COL10A 6q21	LPL 8p21.3
Linkage Study	Chromosomal Loci (Chromosomes 9 – 22)
WEEKS (Weeks et al., 2000)			10q26
WEEKS (Weeks et al., 2001)	9p13		10q26							17q25
WEEKS (Weeks et al., 2004)			10q26							17q25
SCHICK (Schick et al., 2003)			10q26							17q25
MAJEWSKI (Majewski et al., 2003)					12q23- 24		15q11-14 15q25-26	16
BARRAL (Barral et al., 2006)		9q33	10q26
ABECASIS (Abecasis et al., 2004)		9q	10q
IYENGAR (Iyengar et al., 2004)		9q												22q
SEDDON (Seddon et al., 2003)	9p24	9q31	10q26	12q13	12q23		15q21	16p1 2			18p11		20q13
SANTANGELO* (Santangelo et al., 2005)			10q	12q13					16q					22
JUN# (Jun et al., 2005)												19p13	20q13
Possible genes within the linkage locus(loci)		ABCA1 9q31 CoL15A1 TGFBR1 9q22.33	ARMS2 HTRA1 10q26		SCARB1 12q24.3 1		LIPC 15q21.3 IGF1R 15q26.3		CETP 16q21			C3 19p13		TIMP-3 22q12.3