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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Nat Struct Mol Biol. 2012 Jun 3;19(7):671–676. doi: 10.1038/nsmb.2320

Figure 3.

Figure 3

ALKBH2 probes the stability of a base pair to detect DNA damages. (a) Side view of the CG structure. The approximate location of a flipped base is indicated with a magenta box and that of the orphaned base (which could have multiple conformations) is indicated with a dashed cyan box. (b) Overlay of the 1-meA structure (3BTY) and the CG structure. A clear shift of the hairpin loop is highlighted. The protein portion of 3BTY is shown in cyan and the DNA part is omitted for clarity purpose.