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Cytisine and Varenicline potency and efficacy, peak current data
| Cytisine | Varenicline | |||
|---|---|---|---|---|
| Accessory subunit |
EC50 µM |
Imax relative to AChmax |
EC50 µM |
Imax relative to AChmax |
| α3 | 1750 ± 300 | 0.34 ± 0.03 | 16 ± 5 | 0.54 ± 0.06 |
| β4 | 214 ± 32 | 0.16 ± 0.01 | 4.5 ± 1.4 | 0.11 ± 0.01 |
| α5 | 180 ± 8 | 0.17 ± 0.01 | 5.8 ± 0.9 | 0.16 ± 0.01 |
| α5D376N | 309 ± 43 | 0.21 ± 0.01 | 6.5 ± 1.5 | 0.15 ± 0.01 |
