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. Author manuscript; available in PMC: 2013 Sep 1.

Published in final edited form as: Neuropharmacology. 2012 May 11;63(4):538–546. doi: 10.1016/j.neuropharm.2012.04.035

Table 4.

Species dependent effects on α3β4 responses using monomeric constructs

Acetylcholine potency, peak current data
Species	EC₅₀, µM

human α3β4	131 ± 7
rat α3β4	127 ± 6

	Cytisine		Varenicline
Species	EC₅₀ µM	I_max relative to ACh_max	EC₅₀ µM	I_max relative to ACh_max
human α3β4	890 ± 120	0.59 ± 0.03	5.6 ± 1.8	0.40 ± 0.03
rat α3β4	520 ± 50	1.10 ± 0.04	28 ± 3.2	0.39 ± 0.02