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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Exp Neurol. 2012 May 1;236(2):298–306. doi: 10.1016/j.expneurol.2012.04.013

Figure 3.

Figure 3

Downregulation of pAkt levels in HIV/gp120 transgenic mice and human HIV-1 brains. Immunoblot and densitometric estimates of pAkt/Akt levels. (A) Synaptosomes of HIV/gp120 transgenic mice showed a significant decrease in pAkt/Akt levels compared to wt littermate animals. (B) Forebrain of HIV/gp120 transgenic mice also showed a significant reduction in pAkt/Akt levels compared to wt animals. (C) pAkt/total Akt ratio in frontal cortex of patients who were normal/HIV- (and unimpaired on neuropsychological testing), HIV+/unimpaired, and HIV+/HAND. Only the subjects with HAND showed a significant reduction in pAkt/Akt levels. Note that pAkt/Akt ratio tracked more closely with neuropsychological scores than with neuropathological assessments (Table 2). Values in histograms are mean + S.E.M. from n ≥3 experiments (*P < 0.05, ** P < 0.01).