Table 1.
Proteomic fingerprint of differentially regulated proteins (≥1.5 fold) in synaptosomal isolates from HIV/gp120 transgenic mice compared to wild-type animals*
| ID | Symbol | Entrez Gene Name | Average Fold Change |
|---|---|---|---|
| Upregulated Proteins | |||
|
| |||
| IPI00649033 | GFAP | glial fibrillary acidic protein | 3.2 |
| IPI00351246 | MPP3 | membrane protein, palmitoylated 3 | 3.0 |
| IPI00277001 | PSMA4 | proteasome (prosome, macropain) subunit, alpha type, 4 | 2.7 |
| IPI00761566 | ARRB1 | arrestin, beta 1 | 2.3 |
| IPI00227299 | VIM | vimentin | 2.2 |
| IPI00474073 | MAPRE2 | microtubule-associated protein, RP/EB family, member 2 | 2.2 |
| IPI00468204 | AMPD3 | adenosine monophosphate deaminase (isoform E) | 2.1 |
| IPI00131292 | SLC22A4 | solute carrier family 22 member 4 | 2.1 |
| IPI00120798 | SYT12 | synaptotagmin XII | 2.1 |
| IPI00626662 | ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 2.1 |
| IPI00830249 | HTRA2 | HtrA serine peptidase 2 | 2.1 |
| IPI00114801 | INPP1 | inositol polyphosphate-1-phosphatase | 2.1 |
| IPI00620701 | RABGGTA | Rab geranylgeranyltransferase, alpha subunit | 2.0 |
| IPI00845733 | PPM1H | protein phosphatase 1H (PP2C domain containing) | 2.0 |
| IPI00128945 | PSMB2 | proteasome subunit, beta type, 2 | 2.0 |
| IPI00857710 | COPS4 | COP9 constitutive photomorphogenic homolog subunit 4 | 1.9 |
| IPI00754071 | PRDX6 | peroxiredoxin 6 | 1.9 |
| IPI00830393 | COPS6 | COP9 constitutive photomorphogenic homolog subunit 6 | 1.9 |
| IPI00132250 | EIF3E | eukaryotic translation initiation factor 3, subunit E | 1.9 |
| IPI00762185 | MPST | mercaptopyruvate sulfurtransferase | 1.9 |
| IPI00224045 | CHAT | choline acetyltransferase | 1.8 |
| IPI00894579 | PGD | phosphogluconate dehydrogenase | 1.8 |
| IPI00331745 | LXN | latexin | 1.8 |
| IPI00116138 | HARS2 | histidyl-tRNA synthetase 2, mitochondrial | 1.8 |
| IPI00857222 | OXNAD1 | oxidoreductase NAD-binding domain containing 1 | 1.8 |
| IPI00608064 | FECH | ferrochelatase (protoporphyria) | 1.7 |
| IPI00876210 | CNIH3 | cornichon homolog 3 | 1.7 |
| IPI00310105 | PTK2B | PTK2B protein tyrosine kinase 2 beta | 1.7 |
| IPI00132575 | COTL1 | coactosin-like 1 (Dictyostelium) | 1.7 |
| IPI00126048 | PSMD13 | proteasome 26S subunit, non-ATPase, 13 | 1.7 |
| IPI00405121 | UNC13A | unc-13 homolog A | 1.7 |
| IPI00225961 | PHGDH | phosphoglycerate dehydrogenase | 1.7 |
| IPI00649885 | ACADVL | acyl-Coenzyme A dehydrogenase, very long chain | 1.7 |
| IPI00323349 | TJP2 | tight junction protein 2 (zona occludens 2) | 1.7 |
| IPI00469268 | CCT8 | chaperonin containing TCP1, subunit 8 (theta) | 1.7 |
| IPI00317309 | ANXA5 | annexin A5 | 1.7 |
| IPI00875497 | CRAT | carnitine acetyltransferase | 1.7 |
| IPI00284521 | DOCK3 | dedicator of cytokinesis 3 | 1.7 |
| IPI00112630 | GLOD4 | glyoxalase domain containing 4 | 1.6 |
| IPI00460631 | ICA1 | islet cell autoantigen 1 | 1.6 |
| IPI00454082 | KIF21A | kinesin family member 21A | 1.6 |
| IPI00118821 | PAFAH1B2 | platelet-activating factor acetylhydrolase Ib, subunit 2 | 1.6 |
| IPI00624863 | PAICS | phosphoribosylaminoimidazole carboxylase, | 1.6 |
| IPI00222515 | PSMD11 | proteasome 26S subunit, non-ATPase, 11 | 1.6 |
| IPI00649914 | MCART1 | mitochondrial carrier triple repeat 1 | 1.6 |
| IPI00462789 | PSMC5 | proteasome 26S subunit, ATPase, 5 | 1.6 |
| IPI00869359 | CCDC132 | coiled-coil domain containing 132 | 1.6 |
| IPI00421218 | TLN2 | talin 2 | 1.6 |
| IPI00223497 | PDE1A | phosphodiesterase 1A, calmodulin-dependent | 1.6 |
| IPI00130225 | SNX4 | sorting nexin 4 | 1.6 |
| IPI00553576 | ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 | 1.6 |
| IPI00322312 | ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 1.6 |
| IPI00845557 | CTBP1 | C-terminal binding protein 1 | 1.6 |
| IPI00755161 | OSBP | oxysterol binding protein | 1.6 |
| IPI00884508 | SLC2A1 | solute carrier family 2, member 1 | 1.6 |
| IPI00648173 | CLTC | clathrin, heavy chain (Hc) | 1.5 |
| IPI00759948 | GSN | gelsolin (amyloidosis, Finnish type) | 1.5 |
| IPI00116112 | DCTN2 | dynactin 2 (p50) | 1.5 |
| IPI00751036 | EXOC1 | exocyst complex component 1 | 1.5 |
| IPI00135345 | NUDT2 | nudix (nucleoside diphosphate linked moiety X)-type motif 2 | 1.5 |
| IPI00379202 | LOC1001 | similar to kinase D-interacting substrate 220 | 1.5 |
| IPI00330523 | PCCA | propionyl Coenzyme A carboxylase, alpha polypeptide | 1.5 |
| IPI00889265 | NCDN | neurochondrin | 1.5 |
| IPI00467223 | NCKIPSD | NCK interacting protein with SH3 domain | 1.5 |
| IPI00169524 | TRHDE | thyrotropin-releasing hormone degrading enzyme | 1.5 |
| IPI00341302 | C8ORF38 | chromosome 8 open reading frame 38 | 1.5 |
| IPI00312752 | SH3GL1 | SH3-domain GRB2-like 1 | 1.5 |
| IPI00756786 | SH3GLB2 | SH3-domain GRB2-like endophilin B2 | 1.5 |
| IPI00131695 | ALB | albumin | 1.5 |
| IPI00317711 | HSPA4L | heat shock 70kDa protein 4-like | 1.5 |
| IPI00116277 | CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 1.5 |
| IPI00331174 | CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 1.5 |
| IPI00229893 | MARK4 | MAP/microtubule affinity-regulating kinase 4 | 1.5 |
| IPI00314467 | PSMB3 | proteasome subunit, beta type, 3 | 1.5 |
| IPI00114279 | SLC1A3 | solute carrier family 1 member 3 | 1.5 |
| IPI00473685 | USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 1.5 |
| Downregulated Proteins | |||
| IPI00554917 | CLCN6 | chloride channel 6 | -2.7 |
| IPI00315794 | CYB5B | cytochrome b5 type B | -2.5 |
| IPI00553357 | KIAA0368 | KIAA0368 | -2.5 |
| IPI00649734 | CROCC | rootletin | -2.4 |
| IPI00117986 | SLC12A9 | solute carrier family 12 (K+/Cl- transporters) | -2.1 |
| IPI00462406 | PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -2.1 |
| IPI00338327 | NDRG3 | NDRG family member 3 | -2.0 |
| IPI00420535 | ISLR2 | immunoglobulin superfamily containing leucine-rich repeat 2 | -1.9 |
| IPI00337980 | RAB21 | RAB21, member RAS oncogene family | -1.9 |
| IPI00121378 | ALCAM | activated leukocyte cell adhesion molecule | -1.9 |
| IPI00658743 | APOO | apolipoprotein O | -1.8 |
| IPI00319973 | PGRMC1 | progesterone receptor membrane component 1 | -1.8 |
| IPI00914696 | ILDR2 | immunoglobulin-like domain containing receptor 2 | -1.7 |
| IPI00133006 | NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, | -1.7 |
| IPI00652675 | LSAMP | limbic system-associated membrane protein | -1.7 |
| IPI00378120 | GLRX5 | glutaredoxin 5 | -1.7 |
| IPI00555118 | SLC4A10 | solute carrier family 4, sodium bicarbonate transporter | -1.7 |
| IPI00356063 | SCN2B | sodium channel, voltage-gated, type II, beta | -1.6 |
| IPI00125787 | GM14072 | predicted gene 14072 | -1.6 |
| IPI00466672 | CACNA1B | calcium channel, voltage-dependent, N type, alpha 1B | -1.6 |
| IPI00653706 | FAM126B | family with sequence similarity 126, member B | -1.5 |
| IPI00461629 | FXN | frataxin | -1.5 |
| IPI00622742 | CAPN2 | calpain 2, (m/II) large subunit | -1.5 |
| IPI00551399 | EFR3A | EFR3 homolog A | -1.5 |
| IPI00129298 | PALM | paralemmin | -1.5 |
| IPI00127447 | SCARB2 | scavenger receptor class B, member 2 | -1.5 |
| IPI00881362 | ZFPL1 | zinc finger protein-like 1 | -1.5 |
| IPI00323809 | PALM | paralemmin | -1.5 |
| IPI00461730 | PGAM5 | phosphoglycerate mutase family member 5 | -1.5 |
| IPI00331284 | VTI1B | vesicle transport through interaction with t-SNAREs 1B | -1.5 |
| IPI00331463 | ATPIF1 | ATPase inhibitory factor 1 | -1.5 |
*
A positive-fold change indicates an increase and a negative-fold change indicates a decrease in the indicated protein in HIV/gp120 mice.