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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: J Immunol. 2012 Jun 20;189(2):1081–1093. doi: 10.4049/jimmunol.1200318

Figure 2. IL-21R deficiency on donor CD4+ T cells attenuates B cell parameters of cGVHD.

Figure 2

P→F1 cGVHD was induced as described in Materials and Methods. Serum and spleens were collected at the specified time points. A. Absolute number of host B cells. B. Frequency of GL-7+Fas+GC B cells. C. Flow cytometric contour plots of GL-7+Fas+ GC B cells (B cell gate) shown. D. Anti-ssDNA Ab levels were determined by ELISA. E-G. Spleen sections obtained at two weeks were stained for PNA-R+ GC B cells (brown) and B220 (blue). Original magnification x 100. Data are representative of two independent experiments; n=5 mice/group. *=p<0.05.