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. Author manuscript; available in PMC: 2013 Jul 15.
Published in final edited form as: J Immunol. 2012 Jun 20;189(2):1081–1093. doi: 10.4049/jimmunol.1200318

Figure 3. IL-21R deficiency on donor CD4+ T cells ameliorates lupus-like nephritis in P→F1 cGVHD.

Figure 3

P→F1 cGVHD was induced as described in Materials and Methods. A-C. H&E-stained kidney sections of normal F1 control mice, cGVHD mice induced with WT or IL-21R-/- donor cells at 13 weeks after disease induction. Enlarged glomerulus with crescent formation, glomerular sclerosis and interstitial infiltrate are noted in panel B. D-F. Immunofluorescent staining of IgG deposits. Original magnification × 200. G. Proteinuria. H. Glomerulonephritis pathologic scores. Data are representative of two independent experiments; n=5 mice/group.*=p<0.05.